You may opt for a dedicated solution, but at the same time, you may also cherry-pick Social Web solutions, such as used by the Open Notebook Science proponent Jean-Claude. Blogs and wikis are useful tools, and there are several databases where you can submit your data, such as the NMRShiftDB (for NMR spectra assignments) and Chempedia (for diagrams and names).

I love Evernote, while it is not really ment for a laboratory, the features it has complement most of my experiments. And just having a whole database of the experiments on your mobile phone is great!

Wiki's are also an option but i find the lack of flexibility a problem.

@Avi - just posted to another thread started by @Rich that gives some examples of how other organizations are using electronic lab notebooks / informatics. In case it is useful: http://lab.chempedia.com/questions/103/most-compelling-reason-for-using-a-paper-lab-notebook-over-an-electronic-lab-note/116#116