Please supply reaction scheme images for your favorite reactions. I need some good examples to illustrate (using Reaxys) how a given functionality is converted into another functionality and which protocol I need to use so that a third functionality remains stable during the reaction (the use of free sites and generic groups etc). The examples shouldn't be too basic or too complex. I don't have access to a modern organic chemistry textbook.
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My vote would be direct reductive amination for the preparation of secondary and tertiary amines:
My favorite procedure is the one published by Abdel-Magid and coworkers using sodium triacetoxyborohydride at room temperature in halogenated solvents. It has broad functional group tolerance, works well on large and small scale, doesn't use anything particularly hazardous, accepts a large set of commercially-available inputs, and produces products that are highly relevant to drug discovery. |
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