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Morphine needs an acid anhydride to esterfy the 3 and 6 positions so does Inositol Hexnicotinate count as an acid anhydride and would it do the trick to esterfy morphine into Nicomorphine? At first glance it seems possible, dosent it? i mean, if acetic anhydride can yeild 3,6 diamorphine. why not my theory?... just want some input before i go try it out.

Morphine + inositol hexanicotinate = 3,6 Nicomorphine?

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@Ken, thanks for the question. You might get a better response by adding an image depicting your proposed reaction scheme (imageshack can host it: imageshack.us). You can edit the title and body of your question at any time, so feel free to try it and see what you get. – Rich Apodaca Nov 19 at 15:23

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The reference to Inositol hexanicotinate in SciFinder (Reg. No. 6556-11-2) has the following structure (it is a myo-inositol); alt text

These are ester groups not anhydrides so I don't quite see how they could esterify morphine. Transesterification is probably not likely. Sorry but I don't think this reaction of yours would work.

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