Anybody have links to papers covering theory or experiments on the effect of a co-solute on the solubility of a compound?
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If you consider enantiomers to be co-solutes, then the area of resolution technology should have ample data and theory. Here, the effect is being used to purify a mixture by selectively crystallizing away the unwanted enantiomer. For example Polenske has a 2007 paper that treats the specific case of Propranolol. |
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