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This Kilomentor post got me thinking about silica gel as a catalyst for lab-scale synthetic reactions. I've found isolated papers on the subject, such as this one from Rajca.

I have two questions:

  • Have you used silica gel as a catalysts, and if so for which reaction?
  • Where can I find a recent, comprehensive review of the literature on silica gel as a catalyst for lab-scale organic synthesis?

I'm especially interested in something pointing to the solid surface itself, rather than acid catalysis in general, as contributing to the rate acceleration.

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2 Answers

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A great general place to start is "Solid Supports and Catalysts in Organic Synthesis" ed Keith Smith (ISBN 0-13-639998-3). This has a lot of examples of silica-supported catalysts but many just silica reactions. It is a good starting place although my edition is 1992 and has great references.

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have a look at SiliCycle,

www.silicycle.com They have a range of functionalized catalysts on silica gel.

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