1
vote
1answer
115 views
annoying dcm extraction
It's a stupid question but there's one thing which annoys me everytime I do the extraction with solvent heavier than water (e.g. DCM). And this thing is the last drop of solvent wh …
1
vote
2answers
157 views
Best-Practices for Maintaining a Glovebox
How best to maintain our group's several gloveboxes was taught to me orally by our post-docs, so I thought it might be interesting to see what other traditions are out there.
Mark …
1
vote
2answers
122 views
What are the spectroscopic characteristics of common plasticizer impurities?
Derek Lowe's recent post on plasticizer impurities brings to mind a good question: how do you know if you've isolated a plasticizer (from, say, Tygon tubing) rather than your desir …
1
vote
1answer
126 views
How do you quench potassium permanganate?
Potassium permanganate solutions are common in organic synthesis, for both reactions and TLC analysis. What is the best way to quench that solution safety and to dispose of it?
2
votes
4answers
316 views
How do you quench sodium azide?
Is there a way to quench sodium azide in an easy, lazy man way? So that you do not have to worry about hydrazoic acid formation.
1
vote
2answers
274 views
What is the best way to dispose of sodium cyanide waste?
Let's say you're running a reaction with sodium cyanide - what is a good procedure for dealing with the waste stream? (i.e. what is the best way to destroy the cyanide ion?)
1
vote
2answers
427 views
What is the best way to quench an Lithium Aluminum Hydride reduction?
There are a variety of differing procedures for quenching lithium aluminum hydride reductions. Most involve adding water, a 15% NaOH solution and then more water. There may also be …
1
vote
1answer
121 views
Alkyllithium Titration - What’s Wrong With Diphenylacetic Acid?
The procedure I've favored has been titration against diphenylacetic acid (alt). Yet countless procedures have been published (here's a literature survey).
I prefer the diphenylac …
2
votes
2answers
316 views
How do you stop protodeboronation in Suzuki reactions?
Protodeboronation (replacement of the boronic acid or boronic ester with a hydrogen) is a common side reaction in Suzuki reactions. By destroying one of the coupling partners, it c …
2
votes
3answers
689 views
Printable chart of cold bath temperatures?
Where can I find a good printable chart of cold bath temperatures?
It should, for example give the temperatures for various dry-ice/organic solvent mixtures, liquid nitrogen/organ …
1
vote
3answers
340 views
Best way to quench Raney nickel?
Raney nickel is notoriously pyrophoric and needs to be kept and handled wet. Is there any way in the literature of quenching its activity altogether?
(Perhaps flushing/bubbling wi …
2
votes
4answers
240 views
What’s a good cleaning procedure for fritted funnels?
I'm going to ask a slightly different question than general cleaning procedures for glassware. Fritted funnels can't go into a base bath, or you'll ruin the glass frit.
So how do …
2
votes
2answers
143 views
Best Practices for Solvent Stills?
Continuously-operated solvent stills have been the cause of many laboratory fires in the last several years. Although alternatives exist, not every lab is willing to upgrade.
Does …
0
votes
2answers
260 views
Best-Practices Procedure for Working with tert-Butyllithium?
The case of Sheharbano (Sheri) Sangji serves as a reminder to respect and understand the materials in a research lab. Even then, things can go wrong.
Where can I find a detailed, …
3
votes
4answers
475 views
What’s your glassware cleaning procedure?
A long time ago, when I was still in organic chemistry, I practically found it better to not try to get the glassware as clean as possible, but do be fine with 99.9% clean (I never …
